Do partial AZFc deletions affect the sperm retrieval rate in non-mosaic Klinefelter patients undergoing microdissection testicular sperm extraction?
Do partial AZFc deletions affect the sperm retrieval rate in non-mosaic Klinefelter patients undergoing microdissection testicular sperm extraction?
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Abstract Background The purpose of this study is to evaluate the prognostic factors for sperm retrieval and determine if Y chromosome deletion is associated with deleterious effects on spermatogenesis in non-mosaic Klinefelter patients.Whether Y chromosome deletion determines the sperm retrieval rate in non-mosaic Klinefelter patients has not yet been addressed.Methods We retrospectively collected medical records of azoospermic patients Training Equipment from Sep 2009 to Dec 2018, and enrolled 66 non-mosaic 47, XXY patients who were receiving mTESE.The predictive values of patients age, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin, estradiol and Y chromosome deletion were assessed for successful sperm recovery.
Results Testicular sperm recovery was successful in 24 (36.4%) of 66 men.The mean age (36.0 vs.
36.6 years), and levels of FSH (30.0 vs 36.9 IU/L), LH (17.
7 vs 21.9 IU/L), testosterone (2.4 vs.2.
1 ng/ml), prolactin (9.1 vs.8.8 ng/ml), and estradiol (19.
4 vs.22.3 pg/ml) did not show any significant difference when comparing patients with and without successful sperm retrieval.Partial deletion of azoospermic factor c (AZFc) was noted in 5 (20.
8%) Structural Material of 24 patients with successful sperm retrieval, including three b2/b3 and two gr/gr deletion cases, whereas 4 (9.5%) of 42 patients with unsuccessful sperm retrieval were noted to have AZFc partial deletion (one b2/b3, one sY1206 and two gr/gr deletion), though the difference was not statistically significant (p = 0.27).Conclusion According to present results, age and AZFc partial deletion status should not be a deterrent for azoospermic males with non-mosaic Klinefelter syndrome to undergo mTESE.